Your Mast Cell Activation Syndrome Questions Answered Functionally

What is a Mast Cell?


A mast cell is an immune cell that helps with triggering immune reactions such as the inflammatory response and allergic reactions. It does this by creating stores of chemicals known as granules, which can then be released into nearby tissues if the mast cell is stimulated (for example, in the presence of an allergen).


Macrophage vs Mast Cell


Sometimes immune cells can get confused. Mast cells are NOT Macrophages, and serve a
specific function in mediating tissue cell immune response through chemical release that macrophages do not share. Macrophages are more oriented toward foreign body detection and antigen presentation.


What is Mast Cell Activation Syndrome?


Mast cell activation syndrome (or MCAS) is when Mast cells (as described above) trigger an immune response at inappropriate times (without it being beneficial). In this case, the chemical granules are released by the mast cells affecting the surrounding tissues, causing physiological effects that are sudden, serious, and unnecessary.


MCAD vs MCAS vs Systemic Mastocytosis


MCAD or (Systemic) Mast Cell Activation Disease, is an umbrella term for Mast Cell diseases and disorders. This umbrellaed group is characterized by two features. Firstly, the atypical release of chemical granules, triggering an immune response. Secondly, the atypical grouping or spread of persistent dysfunctional Mast Cells.


One such disease under this umbrella is Mast Cell Activation Syndrome (MCAS), which takes on the first mode of effect (i.e. it involves the stimulation of cells to release chemical triggers).


Another is Systemic Mastocytosis. Systemic Mastocytosis involves the atypical proliferation of persistent mast cells. This tends to be more severe than MCAS as the condition tends to become progressively worse over time.


Can you have both MCAS and Mastocytosis?


Yes. And the conditions will almost certainly compound each other’s negative effects.


Symptoms of MCAS:


MCAS results in anaphylaxis, and symptoms are consistent with it as a general condition.


That means:

  • Cardiovascular issues such as low blood pressure, feeling faint, or a racing heartbeat.
  • Classic allergy skin symptoms such as itchy nose (or skin in general), hives and red swelling.
  • Gastrointestinal issues ranging from bloating to diarrhea 
  • Breathing issues such as shortness of breath, mucus blockages and wheezing.
  • Brain fog, dizziness, and minorly impaired cognition.


*This list is non-exhaustive.


These may not sound like end-of-the-world issues, but getting them spontaneously can be extremely disruptive to a normal healthy life. Living with MCAS can be very frustrating and can affect confidence and self-esteem. Furthermore, in combination with other health issues such as asthma or heart health problems, MCAS can raise the risk of serious adverse events.


In serious cases, these symptoms can manifest in the extreme and are life-threatening.


Mast Cell Activation Syndrome Neurological Symptoms


MCAS may have further symptoms in the neurological department which are still being explored. Mast Cell Activation Disease (MCAD), of which MCAS is a specific form, has been associated with a wide array of neurological conditions. These include:


Furthermore, due to the dense concentration of mast cells in the region of the brain closest to the pituitary gland and the hypothalamus, the mast cells are expected to have a significant effect on the hormonal systems and the HPA (Hypothalamic-Pituitary-Adrenal axis). The mast cells in the brain respond to stress signals from the hypothalamus and induce a variety of effects on the central nervous system.


What are some common MCAS Triggers?


MCAS symptoms can be brought on by a wide array of triggers, some of the common ones include:


  • Smells and Odours (this can vary depending on the individual).
  • Certain foods (again this can vary depending on the individual).
  • Mold
  • Cleaning Chemicals
  • Vibrations
  • Friction with the skin
  • Venoms (such as a bee sting)
  • Dust


*This list is non-exhaustive.


If you have MCAS you might experience some of these, all of these or even none of these (but other triggers) at varying levels of potency. MCAS is defined by the hyperactivation of the cells, not by the triggers that it reacts to in any given person.


Can Mast Cell Activation Syndrome Cause Cancer


NO. Mast cell activation syndrome has not been shown to be a cancer risk. HOWEVER, other mast cell activation diseases, such as systemic mastocytosis, CAN become cancerous.


Can you Die from MCAS


YES. Mast cell activation syndrome commonly causes anaphylaxis, which, if left untreated, can cause death. Anaphylaxis deaths are very uncommon, with only a
couple hundred deaths per year. What’s more, is that only a percentage of these will be MCAS-related. Nevertheless, do not underestimate the threat of anaphylaxis and always carry a rescue aid (such as an EpiPen).


Other symptoms of MCAS could lead to death as well; however, these would typically be less direct and, therefore, are unmeasurable. Think dizziness. If you became dizzy, fell, and died, people may not be able to determine the cause. This is, of course, highly unlikely.


Is MCAS a Disability


MCAS is a disability. MCAS can cause an individual to be unable to perform certain tasks, or in certain environments. It’s easy to imagine how becoming short of breath and faint can cause a disruption to daily activity. This qualifies it by such definitions as that of
Merriam-Webster.


Whether it is recognized as such in any given jurisdiction for benefit purposes or is considered a severe enough disability to merit this kind of aid is a matter of governance. In the United States,
MCAS can be sufficient for disability claims based on severity.


Mast Cells and Asthma


Mast Cells play a key role in asthma
, which is exacerbated by the presence of MCADs such as MCAS or mastocytosis. Mast cells are especially notable in allergic asthma (a common subtype of asthma that triggers in relation to specific allergens) and release chemicals that directly result in airway constriction. The severity of asthma can be related to mast cell density and the location of mast cell origin points in the lung.


What does day-to-day life look like for an MCAS Sufferer?


The day-to-day experience of an MCAS sufferer will be highly bio-individualised. That is to say, it will depend on 


1. The symptoms they typically have. 

2. The severity of their condition. 

3. Their management and treatment methodologies of the condition. 

4. The triggers they may be exposed to on a given day.


A sufferer’s experience can often be characterized by a compulsive situational awareness with the intent of evading triggers and subsequently reducing their symptoms. This is a highly stressful but ultimately necessary behavior for someone with the condition, in a similar sense to how one might treat a typical severe allergy.


MCAS sufferers should ALWAYS carry an EpiPen (Self-injectable Epinephrine), which can be life-saving in case of sudden anaphylaxis.


A typical person with MCAS, despite these challenges, will be able to engage in normal activities, especially with assistive measures (such as well-cleaned work space).


Symptoms can be expected on a daily basis should the sufferer not maintain good awareness of potential triggers, and even then, it is still very possible that symptoms will arise. This is especially challenging when triggers are unavoidable (e.g. pollen counts).


Helpful Behaviors when Living with MCAS


Listing trigger events can help you build a picture of what you typically react to. You can then use this to guide future behavior, such as purchasing choices.


Indeed, maintaining a clean house can be very helpful as dust particles are a very common MCAS trigger. Use natural cleaning products to avoid potential exacerbation of symptoms. Check out www.ewg.org for an easy guide to clean products.


Use a mask and gloves when cleaning to minimize exposure to whatever chemicals you do use.


Always carry a rescue aid such as an EpiPen.


Avoid NSAIDs where possible (that’s non-steroidal anti-inflammatories such as ibuprofen).


Watch what you eat (more on that when I discuss what functional medicine does in response to MCAS).


Keep fit in other areas of life.


Exercise and MCAS


Evidence suggests that exercise advice applicable to most people is not transferable to MCAS sufferers. MCAS symptoms can actually be triggered, and conditions worsened by intensive exercise.


With that said, it’s still important to be keeping healthy, and keeping healthy involves exercise.


It’s advisable to stay active with gentle exercises such as yoga or pilates. 


Swimming can be especially beneficial for MCAS sufferers as it is good for strengthening the lungs but can still be gentle.


Weight lifting is also a good option, as moderate loadbearing can help to offset the risk of osteoporosis faced by someone with MCAS.


When exercising, it is important to be mindful of the possibility of a sudden trigger and ensure rescue aids are near at hand.


Who treats MCAS?


Western Medicine provides treatment for MCAS, as do alternative functional therapists like me.


Diagnosis of MCAS can be challenging due to overlap with other conditions (including other MCADs), and treatment can also be difficult as the episodes of MCAS symptoms are idiopathic (meaning we don’t know for sure how they are triggered, or it’s exceedingly difficult to determine).


Is there a cure for Mast Cell Activation Syndrome (MCAS)?


It’s controversial. Western Medicine would say “no”. Many alternative medicinal practices would say, “Yes, in many circumstances, but not always”. 


What is the Western Approach to MCAS?


The Western approach prioritizes patient relief, which is certainly important with a condition as impactful as MCAS. 


This means rapid diagnosis and treatment with prescription medication (generally blockers for the chemicals released by the mast cells).


The most effective way for Western medicine to diagnose the condition is to do a blood test looking for clues in tryptase, histamine, and prostaglandin levels. They will also look for symptoms characteristic of allergic reactions and will test you with antihistamines and blockers for the mediator chemicals released by mast cells to see how you react. 


One such medicine might be loratadine, a common antihistamine thought to be a mast cell stabilizer. You can purchase it over the counter in most jurisdictions, and so trying it is a diagnostic test you can perform yourself should you wish. It is, of course, wise to consult a physician first if you have any cause for concern with taking a new medication.


On the cutting edge of Western medicine is a treatment called Xolair (Omalizumab). It is an injectable medication that has shown
significant promise in management of MCAS symptoms. Xolair for MCAS is becoming more and more common and has been recommended as a monthly prescription for sufferers. This would, of course, be indefinite, but pending a pronounced change in the causative factors for sufferers, treatment with Xolair could be life-changing. That said, Xolair is not without its own risks, with the manufacturer noting potential side-effects such as cancer, heart conditions, parasitic infections, and other unpleasantness. It may be a worthwhile trade for some, however, as living with MCAS is not easy.


Nevertheless, once a diagnosis is made,
Western medicine declares you incurable and will continue to prescribe medication to you for symptomatic relief for the rest of your life. Indeed, genetics does seem to play a role in MCAS, but the jury is out on whether this is predispositionary or entirely heritable.


What is the Functional Medicine Approach to MACS?


Less precise in diagnosis (not that there was much precision on offer to begin with), but more hopeful in prospects; functional medicine is fine with you taking symptomatic cures, provided they are not harmful, but it itself focuses on improving factors that could cause disorderly mast cell behavior.


This comes as part of a broader approach to living a healthy life and treating the body as one big interconnected system. That being the case, diagnosis is not *such* a priority, but getting you to a place where MACS is a thing of the past is.


Some things that functional medicine attempts to help you rectify (using highly personalized diet and lifestyle routines) are:

  • Hormonal Cascade and Estrogen Levels
  • Gut Health and Dysbiosis
  • Autoimmune conditions
  • Mental Stress and Stressor Management


All of these factors will play a role in MCAS, and functional medicine will help you bring balance to them. Even in the instance that you are genetically predisposed to Mast Cell Activation Syndrome, the reduction in symptom expression you stand to experience from the resolution of dysfunctions can improve your quality of life markedly.


Is it, in that case, possible to cure MCAS with functional medicine practice? Since there aren’t peer-reviewed studies proving it, the jury is still out, but I am a proponent of the idea that it is. There is still a lot we need to learn about gene expression, and we know that genes are turned on and off in cells, which then multiply to replace old cells. Is there scope for this mechanism, or indeed some other, to result in a full cure of MCAS? We don’t know, but if it cures your symptoms while you try and find out, then I’d say it’s not a bad bet.


If you have MCAS, you should strongly consider talking to a functional medicine practitioner. Given that Western medicine brands the condition as incurable, there is very little to lose from booking a
free discovery session to feel out your options.


In Conclusion / TL;DR


To sum up, MCAS is a hyperactivity of immune response cells.


It’s a serious condition not to be confused with its close counterpart, mastocytosis, which is even more serious.


It can be brought on by a number of common triggers on a daily basis and the symptoms are wide-ranging.


It is non-cancerous (unlike some other similar conditions) but is lethal if not well managed.


Daily life can be difficult for the MCAS sufferer, but there are behaviors that can help.


Western medicine has some promising treatments for MCAS symptoms but the consensus is that MCAS is permanent. 


Functional Medicine also has promising treatments, but these are more targeted at pathology in order to better manage activation.


Heidi Toy Functional Medicine Blog

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Balding affects everyone to some degree eventually but despite that it can be extremely distressing especially for women and younger age groups. I personally found myself balding in my early thirties which, man, really did not feel good looking in the mirror, especially as a young woman. Anyways I totally get it, but I’ve found my way back from balding to a healthy head of hair, and hopefully with the information here you can too. I go through the difference between hair loss and hair shed in my recent article on the topic . If you’re having hair loss, you are balding. Hair shed is a different kettle of fish, so it may be worth reading. Above, I went over some factors that can cause your hair to fall out and stay out. Now, I’m going to dive deep into some of the patterns balding takes, how to identify which one you are experiencing, and explain exactly what they tell us about your health in order to give you solutions that will actually help. Whether you see a functional practitioner, your family doctor, or a dermatologist, some of the key factors they use in determining how to help you stop hair loss or shed are already evident. What Causes Most Forms of Balding Most forms of balding are a combination of 4 things. Age, genetics/hereditry factors, hormonal imbalances and autoimmunes. Age As you get older hair follicle rest phases just start to get longer, blood flow worsens and follicles will become dormant. Just like with all age related deterioration, we can obstruct it’s progression, but I’m not selling an immortality pill here ya know. Furthermore age will contribute to other factors such as hormonal imbalance. Hormonal imbalance The primary hormone that impacts hairloss is DHT (which is androgenic and comes from testosterone). The simple explanation is that either your hair follicles are more receptive to DHT (as is genetically predisposed) or your DHT levels are very high. It is not, however, the only factor in play. Estrogen and progesterone keep your hair in it’s growth phase for longer, and with testosterone converting to both DHT and Estrogen it should be a significant point of focus in hair loss investigations. Often hormonal imbalances can be a warning sign of problems with the gonads (ovaries and testes), hence why hair loss or excessive growth can be associated with PCOS. Another major issue that can wreck your hormone balance is stress, and thats the main reason I personally started losing my hair in my 30s. Hereditary factors That means your genetics. Some people have blue eyes, some people have brown eyes, and some people lose their hair faster. It’s just one of those things. But this isn’t just “you will lose your hair” it’s a question of what predispositions we are working with here. Are you male or female, and so predisposed to certain patterns of hairloss? Are you predisposed to an illness that could be efffecting your hair? Are you predisposed to a higher level of DHT than average? Are you predisposed to producing high levels of cortisol (the stress hormone, which by the way is how stress destroys your hormone cascade)? In a lot of these cases we can stand against the power of genetics, and, despite your predispositions, get you your hair back. AutoImmunes Autoimmunes (where the immune system turns on the body and attacks healthy tissue) can cause hair loss through a number of different mechanisms such as attacking the hair follicles or contributing to hormonal imbalances. A couple examples might be Lupus or Hashimoto’s Thyroiditis. “Normal” Hair Loss (Androgenetic Alopecia) I say normal… Is it ever really “normal” to lose your hair? I suppose what I’m trying to say is that everyone will lose their hair eventually, and when they do with will be from Androgenetic Alopecia. That is to say, by the combined effects of genetic predispositions, age and hormone levels. This is the typical cause of balding in healthy adults and is, at a certain point, a normal part of aging. However, nobody want’s to lose their hair, and we can do things to buffer the onset of androgenetic alopecia, especially if it’s caught early. Androgenetic alopecia tends to manifest in two patterns, male and female. They are both quite distinctive though men have more pronounced symptoms. With that all being said, before we continue to a breakdown of these two patterns, it’s important to note that just because you hair loss matches one of these patterns does not mean that it is normal natural hair loss. There may be underlying causes that trigger a hairloss pattern that appears to be natural age related hair loss but is in fact more concerning from a health perspective. Key Signs of Male Pattern Baldness: What is Male Pattern Baldness: Male pattern baldness, while not totally exclusive to men, is generally the pattern in which men will lose their hair through androgenetic alopecia. That’s the sort of hair loss which happens naturally over time as we age, though it may be stimulated for other reasons. It’s characterisd by a receding hairline with recession at the temple as well as balding at the crown of the head. When concerned about, and looking for early signs of a receding hairline, looking at the context is always a great place to start. The most common cause of a receding hairline is androgenic activity (aka testosterone and related structures) combined with the hereditary factor (such as being male). If you are taking any medications, prescribed or otherwise, which might replace or increase testosterone, then the increased androgenic activity makes hair loss par for the course unless you take action to stop it. It’s also worth considering if you have had greater recent androgenic activity based on your lived experience. Have you experienced an increase in acne levels? Have you found yourself with a shorter temper? Perhaps, while hair is disappearing in some places, it’s becoming more forthcoming in others? All of these are signs of raised testosterone levels. If you are having these signs, and especially where other factors aren’t really in play, it is wise to discuss with a doctor, as raised testosterone levels can indicate that there is something that requires investigating in the gonads (testes or ovaries). Of course, in line with that, there are functional strategies we can employ to correct hormonal imbalances too. Did you know that Stress (there it is again) can increase testosterone levels? This is just one of a number of ways in which it can contribute to hair loss. This is one area where functional strategies will blow your MD’s take out of the water, but more on that later. Finally for context, on a herediary note, consider close family members. Does your father or mother have a receding hairline? Are your siblings having similar challenges? Don’t hesitate to reach out to them to discuss the topic as it can provide valuable insight on the nature of your condition. Next, it’s time to look at the forehead and scalp. Give your hair a quick brush at the back of the scalp then in the area of concern. Is there a difference in the shed? Remember hair shedding is not hair loss, but if you are experiencing localized shedding, it could help explain your concern and guide your efforts to stop the hair falling out. Do you have sensitivity in the scalp? Hair loss is often associated with increased discomfort, sensitivity and itchiness. Now take a photo. The easiest way to know for sure if you have a receding hairline is to take some photos and compare with photos from a week or two later. Just look for changes in the forehead size and hairline, especially at the temples. Key Signs of Female Pattern Baldness: What is Female Pattern Baldness: Female pattern baldness is less commonly talked about, mostly because it has a lower profile, and occurs much later in life than baldness typical of males. It’s also known as hair thinning (though this term has other applications) because its pattern is distributed accross the scalp. It occurs all over the scalp, with no particular area becoming markedly worse. However, it can appear as though the hairline is threatening to recede, or that the location of your usual parting is losing hair more rapidly, due to the fact that the thinning of the hair will be more noticeable where the hair roots are made visible. When concerned about female pattern baldness, as with male pattern baldness, looking at the context is always a great place to start. Again, hereditry and hormonal effects play a significant role in hair thinning that occurs with female pattern baldness. Unfortunately, we don’t have as much research on the issue as with the male pattern. For women, fluctuations in progesterone and estrogen can correlate with hair loss (yes, it can effect men, but it’s definitely not the first place a man should look). That means events like menopause (especially menopause) or childbirth can trigger hair shed and loss. It also ties into the stress response, as demand on cortisol production (the stress hormone) effects your progesterone levels, and not in a good way. Concerns with testosterone and DHT levels still play a role here though, especially as a reduction in estrogen production can cause an increase in DHT. It’s not clear whether the lower exposure of female hair follicles to DHT is what differentiates the actual pattern of hair loss, or whether women have different adrogen receptor distribution on the scalp (oh look, we are getting a little bit technical). It does seem that women can, get male pattern hairloss from very high levels of DHT but whether DHT is the primary causative factor in female pattern hair loss despite the obvious pattern difference is an open discussion. Regardless, it is definitely related, and so the same questions apply regarding androgen levels, those being: Are you on medications which could impact your hormone cascade? Are you experiencing raised acne levels? Are you experiencing abnormal aggression levels? Are you experiencing hair growth in areas not on the scalp? Would you say your stress levels have been elevated? And again, for the hereditary component, look at close family members and talk to them for information on their experience if they may have or may have had similar issues. It is important to consult a doctor regarding significant hormonal fluctuations. As stated previously these can be cause by conditions of the gonads (testes and ovaries). Nevertheless, there are powerful funtional strategies to combat hormonal imbalance, which may even given some symptomatic relief in spite of an underlying condition. Now, take a photo of yourself. Like with a receding hairline one of the most effective ways to check for female pattern baldness is comparison over time. Make it a habit to take a photo of yourself in the same lighting and angle once a week, female pattern baldness is generally slower onset and takes time to manifest, so regular review will help prove the issue and document progression to show whoever you go to for help. “Abnormal” Hair Loss Besides your typical baldness patterns (male and female androgenetic alopecia) there are other manners that hair loss can present that suggest less natural origins. Most of them can link in with each other, and it is possible to have them alongside your natural hair loss, which can be a bit confusing. The three most significant would be Cicatricial (Scarring) Alopecia, Alopecia Areata, and Traction Alopecia. What is Traction Alopecia? Traction alopecia is very simple, really. It’s hair loss because the hair follicles are being pulled on over time (acute ripping out of the hair is another matter and not one we’ll handle here). It will be localised to the area that has had traction applied. This could be a cause for losing your hair on one side of your head if you have had traction applied there. What causes Traction Alopecia? Maybe you are tying your ponytail too high and tight. Maybe you are fidgeting with your hair more vigorously due to stress. Really anything which pulls on the hair over an extended period could cause traction alopecia. Deserving of a specific mention might be mental health conditions which involve you pulling your hair, whether as the condition itself (tricotillomania) or as a coping mechanism. Key Take Aways for Traction Alopecia Most of the time, hair lost to traction alopecia can be reclaimed. Only in very pronounced cases where permanent damage to the hair follicle occurs, will the hair be unable to regrow. Traction alopecia won’t happen in a single moment. If you wear your hair down and you’ve brushed your it and have pulled out a clump of hair, unless you were really (and I mean really) going at it, then it wasn’t traction alopecia, and you have to look at other potential causes for hair shed. What is Cicatricial (Scarring) Alopecia As the name (scarring, not cicatricial) suggests, this form of hair loss is said to have occurred when the lack off hair growth is caused by scarring of the hair follicles. It can be very uneven, so if you are finding less hair on one side of your head (you’re losing hair on one side of your head) or you are noticing a patchy asymmetrical hair loss then you are very possibly dealing with scarring alopecia. What Causes Cicatricial (Scarring) Alopecia There are a wide array of potential causes for scarring alopecia and considering your own recent circumstances will help guide you to the cause of yours. One cause would be autoimmune conditions, most notably Lupus. Conditions such as Lupus can cause rashes and scarring, when these occur on the scalp hair loss occurs which can, unfortunately, be permanent (due to damage to the hair follicles). Physical traumas can cause scarring alopecia, so if you are having uneven or onesided hair loss, consider if you have had any major traumas to the area, even if they were a long time ago. Non-autoimmune rashes and skin conditions also play a role, one key example would be eczema which is well known for causing quite pronounce hairloss if allowed to persist. Key Take Aways for Cicatricial (Scarring) Alopecia It refers to damage of the hair follicles and for the most part is permanent. It can be caused by health conditions, such as autoimmunes, but also acute trauma. What is Alopecia Areata This is non-scarring hair loss outwith the usual patterns of hair loss (androgenetic alopecia). Most commonly this will involve a patchy appearance. You may find one patch on a side of your head or you may find many smaller patches. Rarely will there be any symmetry. Alopecia Areata is really a catch-all term, but with so many factors pinned down remaining causes are actually quite limited. What Causes Alopecia Areata Autoimmunes, most prominently Hashimoto’s thyroiditis (which caused my hair loss), are the most common cause of alopecia areata. In the case of Hashimoto’s, there is a reduction in thyroid activity (hypothyroidism) which has been shown to correlate with hair loss. This is thought to be because it low thyroid hormone affects skin cell regeneration, which results in stalling of the hair growth phase cycles. Another cause of alopecia areata would be a reduction in blood flow to a given area, but this is a very rare cause due to the nature of the blood vessels in the scalp. You can also find that poor sleep will cause this kind of hair loss as it weakens the hair follicles (when it is a habitual deficiency). Key Take Aways for Alopecia Areata Most of the time, especially with proper care and treatment Alopecia Areata hair loss is temporary. It’s involves no permanent damage to the hair follicle (non-scarring) but instead turns the follicle off so to speak. From a functional standpoint… There are a lot of actionable steps we can implement to reduce risk of balding and hair loss. These generally encompass reduction of 3 types of stressors on the body. Those would be: Emotional Stress Dietary Stress Pain/Hidden Inflammatory Stress This can help reduce balding and hair loss by: Providing sufficient nutrients to ensure follicles don't fall dormant. Holding autoimmune conditions, like Hashimoto’s Thyroiditis, in remission. Reducing the need for hair related fidget habits and ensuring you have the energy necessary to practice proper hair care. I personally reversed my hair loss using functional medicine, so I know it works and I've helped hundreds of other women do the same. If you want to put a stop to hair loss, get on a free discovery call with me .
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