IBS...an Autoimmune Condition?

The IBS and SIBO Connection...and is it all Autoimmune?

Can IBS (irritable bowel syndrome) be autoimmune?



IBS is a condition that impacts over 45 million people in the US! A subset of patients with IBS have a variant called Small Intestinal Bacterial Overgrowth (SIBO) pronounced "See-Bow"). These two medical conditions commonly coexist and share many of the same symptoms such as abdominal pain, bloating belly distension, and diarrhea. This means if a patient has been diagnosed with IBS, there is a strong likelihood (up to 80% chance) that they also have SIBO.


IBS is generally a diagnosis of symptoms (see above) that occur for a period of time. Once inflammatory bowel disease (IBD) is ruled out by labs, intestinal scoping or biopsy, IBS can be diagnosed. SIBO can be presumed by symptoms, but a confirmatory diagnosed only by lab test. Simply put, IBS is a diagnosis of exclusion. It’s the result of ruling out all other possibilities. 


With proper testing that measures accurately......measuring three microbially-produced gases indicative of SIBO (hydrogen, methane and hydrogen-sulfide). This is important information since the treatment for each elevated gas is unique.


The IBS-Autoimmune Connection

IBS can be autoimmune, but not always. I’m going to tell you a short story to help you understand how IBS can be autoimmune.


Once upon a time in a distant land, a bacterium and his friends went on an adventure. They each packed some food and clothes as well as a canister of endotoxin (just in case they got into a predicament). On the adventure, the friends were accidentally eaten by a human. (Egads!) It was dark and slimy in that creature, so the bacterial adventurers reached into their pockets and pulled out their canisters of endotoxin. Each one sprayed the walls of the human with the contents of their canister. (Early graffiti artists, perhaps?) The endotoxin was not appreciated by humans, and it released those critters in a violent cramp and spray too dirty to describe here. Suffice it to say, it was gross. The human came prepared with more than a diarrheal response. It waged its own defense with antibodies to that endotoxin. In a few days, all was well again. The bacteria were back into the world having other adventures and the human was feeling pretty good.

But unknown to that human, was this: the DNA sequence of those endotoxins looked VERY similar to a protein inside the human gut. This protein is called vinculin. Sometime later, the antibodies that were made for that endotoxin started attacking the vinculin. What started out as host defense, had turned into an autoimmune condition. Or two. Or three.


Some IBS and SIBO are Autoimmune.


Ever heard someone say, "whenever I travel with a group of friends, I am the ONLY one who gets sick." Or, "ever since I had food poisoning....I have had (fill in the symptoms.)" This may very likely be a post-infectious gastroenteritis autoimmune IBS.


So is your IBS autoimmune? Maybe! If you want to dig into the root causes of your IBS and see how I can help, schedule a Discovery Session today.


Don't Miss Out!

Heidi Toy Functional Medicine Blog

By Heidi Toy June 14, 2025
Did you know most people didn’t have refrigerators in their homes until well into the 1900’s? It wasn’t even invented for large scale commercial use until the mid 1800’s [1]. So how did people keep their milk cold and make their food last longer? Fermentation. It sounds like a gross concept, because we often associate fermentation with a bad odor, but foods like cheese, yogurt, sauerkraut and pickles are all fermented foods. And those aren’t gross, are they? Well, some might disagree with me about sauerkraut, but that’s beside the point. Fermented foods are digestive aids. Microscopic living organisms in fermented foods help extend the food’s shelf life, enhance flavor, and help the body absorb minerals. These organisms pre-digest the food, getting rid of harmful components, and create more vitamins and enzymes than the food began with. Enzyme-rich foods have many benefits including [2]: Increase digestibility of food we eat Boost immune system Increase alkalinity; neutralizing pH levels Provide a healthy balance of friendly flora in the gut (Learn more about your microbiome in my other blog posts ) Tone the colon and help with elimination Control cravings for unhealthier foods Eliminate toxins and undigested wastes in the body In the “old days,” people use to ferment all kinds of foods through pickling, canning, pasteurization and added salt. Nowadays, however, large scale fermentation has lost many of its nutritious benefits due to the need for speed to get the product on the shelf as fast as possible and as cheap as possible. The only true fermented foods you will find are sauerkraut, kombucha, yogurt and kefir, beans, wine and beer, some meats (such as salami and pastrami), legumes and nuts (such as tofu, soy sauce and miso), sourdough bread, and various kinds of vegetables [3]. Fun facts about sauerkraut: The Germans “stole” it from the Chinese! Sauerkraut (probably not labeled as such for the Chinese, but the same recipe) was one of the main foods for those who built the Great Wall of China. Genghis Khan brought it to Eastern Europe during an invasion. It also contains high levels of vitamin C, and sailors often took it on long journeys to prevent scurvy.
By Heidi Toy May 14, 2025
How can we best keep blood sugar stable? Do what our body is designed to do – use fat for energy. Our species did not survive the Ice Age because of vanilla coffee lattes and cheesecake. Throughout most of our history, we ate a diet that was likely 50-70 percent fat. Look at the old family photo albums, specifically pictures of people in the first half of the 1900s, before we had so many processed foods. You won’t see many fat people--in fact, most look darn skinny. If they lived on the farm, they ate lots of eggs, meat, milk, and vegetables out of their own backyards. “Diet foods” were non-existent. Heart disease was almost non-existent. Our metabolism is designed to work much better with fats better than with sugar. Fats provide the slow and steady fuel our body likes to use for energy. Think of fats as a slow-burning log on the fire. One log (i.e. one meal containing fats) lasts for hours. Starchy carbs, on the flip side, are like kindling. You constantly have to throw more twigs (chips, pasta, bagels) to keep the fire burning. The first step is to know your sugars by reading the labels, and then avoid said sugars as much as possible.
By Heidi Toy May 1, 2025
How Stabilizing Blood Sugar Can Help Put Autoimmune Conditions into Remission and Promote Healing
By Heidi Toy April 14, 2025
Omega-3 and Omega-6 are considered “essential” fatty acids because they cannot be produced by the body--we get them from the food we eat. They are biologically active upon ingestion, which means the body utilizes them right away and cannot store them up for later. They are essential because they help with both inflammatory and anti-inflammatory responses.
By Heidi Toy March 14, 2025
Kill the Candida!
By Heidi Toy March 14, 2025
Hangover or Too Much Yeast?
By Heidi Toy March 10, 2025
Food Cravings Explained: The Hidden Causes of Sugar, Salt, and Carb Cravings (and How to Take Control)
By Heidi Toy February 28, 2025
Why Did I Get Candida and How Can I be Sure?
By Heidi Toy February 17, 2025
Discover How CoQ10 Supports Heart Health, Energy Levels, and More—Especially During Heart Health Month.
Candida yeast overgrowth
By Heidi Toy February 14, 2025
Good Yeast, Bad Yeast
More Posts